Periapical inflammation subsequent to coronal inoculation of dog teeth root filled with resilon/epiphany in 1 or 2 treatment sessions with chlorhexidine medication.

Abstract

INTRODUCTION:

Therapeutic methods that inhibit microbial ingress into filled root canals are desirable. This in vivo study assessed the inhibition of periapical inflammation subsequent to coronal inoculation in canals medicated with 2% chlorhexidine gel and filled with Resilon/Epiphany (Pentron Clinical Technologies, Wallingford, CT).

METHODS:

Six Beagle dogs each had 10 two-rooted premolars treated. In group 1 (n = 36 roots), 1 root/tooth had the canal conditioned with Primer Epiphany, filled with Epiphany sealer and Resilon core in 1 session, and coronally sealed with PhotacFil. In group 2 (n = 36 roots), the second root/tooth had the canal medicated with 2% chlorhexidine gel for 1 week and then filled and coronally sealed as in group 1. After 3 weeks, canals were exposed to the oral environment for 7 days, inoculated with isologous plaque, and coronally sealed. Negative controls treated as groups 1 and 2 remained sealed. Positive controls had canals unfilled and exposed. Seven months after inoculation, dogs were euthanized; jaw blocks processed for histologic examination; and periapical inflammation (PI) recorded as none, mild, or severe.

RESULTS:

In groups 1 and 2, severe PI occurred in 5 of 65 roots (8%) and mild PI in 18 of 65 roots (28%) with a significantly higher (P = .031) PI incidence in group 2 than in group 1. Negative controls had only mild PI in 9 of 29 roots (31%). Roots medicated with 2% chlorhexidine gel had mild PI significantly more (P = .009) than roots filled in 1 session (more than 2-fold).

CONCLUSIONS:

Intracanal medication with 2% chlorhexidine gel and root filling with Resilon/Epiphany did not effectively inhibit apical periodontitis subsequent to coronal inoculation.

• Authors: João M Santos, Paulo J Palma, João C Ramos, António S Cabrita, Shimon Friedman
• Journal: Journal of endodontics (J Endod) Vol. 40 Issue 6 Pg. 837-41 (Jun 2014) ISSN: 1878-3554 [Electronic] United States
• PMID: 24862712 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 American Association of Endodontists. All rights reserved.

Chemical References

• Glass Ionomer Cements
• Photac-Fil
• Resins, Synthetic
• Root Canal Filling Materials
• Root Canal Irrigants
• epiphany sealer
• resilon sealer
• Chlorhexidine

Topics

• Animals
• Bicuspid (drug effects, microbiology)
• Chlorhexidine (therapeutic use)
• Dental Plaque (microbiology)
• Dental Pulp Cavity (drug effects, microbiology)
• Dental Restoration, Permanent (methods)
• Dogs
• Female
• Glass Ionomer Cements (chemistry)
• Periapical Periodontitis (classification, microbiology)
• Radiography, Bitewing (methods)
• Resins, Synthetic (chemistry)
• Root Canal Filling Materials (therapeutic use)
• Root Canal Irrigants (therapeutic use)
• Root Canal Preparation (instrumentation, methods)
• Root Canal Therapy (methods)
• Tooth Crown (microbiology)
• Tooth, Nonvital (microbiology, therapy)