Long-term outcomes of laparoscopic adrenalectomy for Cushing disease.

Abstract

INTRODUCTION:

In the surgical management of the patients with Cushing syndrome (CS), minimal invasive adrenalectomy (MA) has become the procedure of choice to treat adrenal tumors with a benign appearance ≤6 cm in diameter. Authors evaluated medium- and long-term outcomes of laparoscopic adrenalectomy (LA) for CS or subclinical CS (sCS), performed for ten years in an endocrine surgery unit.

METHODS:

We retrospectively reviewed 21 consecutive patients undergone LA for CS or sCS from 2003 to 2013. Postoperative clinical and cardiovascular status modifications and surgical medium and long-term outcomes were analyzed.

RESULTS:

In each patient surgery determined a normalization of the hormonal profile. There was no mortality neither major post-operative complications. Mean operative time was higher during the learning curve, there was no conversion, and morbidity rate was 6.3%. Regression of the main clinical symptoms occurred slowly in twelve months.

CONCLUSIONS:

LA is a safe, effective and well-tolerated procedure for the treatment of CS and sCS reducing arterial blood pressure, body weight and fasting glucose levels. Following the learning curve a morbidity rate similar to that reported in the MA series for other adrenal diseases is observed.

• Authors: Giovanni Conzo, Daniela Pasquali, Claudio Gambardella, Cristina Della Pietra, Daniela Esposito, Salvatore Napolitano, Ernesto Tartaglia, Claudio Mauriello, Guglielmo Thomas, Angela Pezzolla, Annamaria De Bellis, Luigi Santini, Antonio Agostino Sinisi
• Journal: International journal of surgery (London, England) (Int J Surg) Vol. 12 Suppl 1 Pg. S107-11 ( 2014) ISSN: 1743-9159 [Electronic] England
• PMID: 24862670 (Publication Type: Evaluation Study, Journal Article)
• Copyright: Copyright © 2014. Published by Elsevier Ltd.

Topics

• Adrenal Gland Neoplasms (surgery)
• Adrenalectomy (adverse effects, methods)
• Adult
• Aged
• Body Weight
• Cushing Syndrome (surgery)
• Female
• Humans
• Laparoscopy (adverse effects, methods)
• Male
• Middle Aged
• Operative Time
• Postoperative Complications
• Retrospective Studies
• Treatment Outcome
• Young Adult