Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy.

Abstract

CONCLUSION:

Photodynamic therapy (PDT) is a viable and safe option for early laryngeal cancer that would be less suitably treated with radiation or trans-oral laser surgery (TLS). The cure rates with PDT appear to be comparable to those of conventional therapy, and the voice outcomes are also comparable. In the case of many sarcomas, PDT appears to be an organ- and function-sparing therapy, although it is more costly than other treatments.

OBJECTIVES:

The aim of this study was to show the results of PDT when it is used as a primary treatment of early laryngeal cancer.

METHODS:

We studied the results of PDT when used as a primary treatment. We looked at survival, effect on tumor, side effects, voice, and costs.

RESULTS:

The follow-up period was a median of 59 months. Nine of 10 patients were cured of their laryngeal cancer. PDT alone cured seven patients. All four of the sarcomas were cured using temoporfin. Two of three tumors that involved the anterior commissure were cured using only interstitial illumination with PDT. No serious side effects were noted. The patient's voices were improved after treatment in 5 of 10 cases, and none had a worsened voice.

• Authors: Mathias P von Beckerath, Johan A Reizenstein, Attila L Berner, Kent W O Nordqvist, Fredrik J Landström, Axel Lennart Löfgren, Claes G Möller
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 134 Issue 8 Pg. 852-8 (Aug 2014) ISSN: 1651-2251 [Electronic] England
• PMID: 24856450 (Publication Type: Journal Article)

Chemical References

• Mesoporphyrins
• Photosensitizing Agents
• temoporfin

Topics

• Adult
• Aged
• Aged, 80 and over
• Early Diagnosis
• Female
• Follow-Up Studies
• Humans
• Laryngeal Neoplasms (diagnosis, drug therapy, mortality)
• Male
• Mesoporphyrins (therapeutic use)
• Middle Aged
• Neoplasm Staging
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Retrospective Studies
• Survival Rate (trends)
• Sweden (epidemiology)
• Treatment Outcome