Abstract | OBJECTIVES: METHODS: Sterile pancreatic necrosis (SN) was induced by retrograde injection of 4% taurocholate in the common bile duct of Balb/c mice. Primarily infected pancreatic necrosis (IN) was induced by co-injecting 10(8) CFU/ml Escherichia coli. 10 mg/kg of moxifloxacin was administered prior to pancreatitis induction (AN). After 24 h, animals were sacrificed to examine serum as well as organs for signs of SIRS. RESULTS:
Moxifloxacin significantly reduced bacterial count in pancreatic lysates of animals with infected pancreatic necrosis (IN 4.1·10(7) ± 2.4·10(7) vs. AN 4.9·10(4) ± 2.6·10(4) CFU/g; p < 0.001). However, it did not alter pancreatic histology or pulmonary damage (Histology score: IN 23.8 ± 2.7 vs. AN 22.6 ± 1.7). Moxifloxacin reduced systemic immunoactivation (Serum IL-6: IN 330.5 ± 336.6 vs. 38.7 ± 25.5 pg/ml; p < 0.001), hypoglycemia (serum glucose: IN 105.8 ± 12.7 vs. AN 155.7 ± 39.5 mg/dl; p < 0.001), and serum aspartate aminotransferase (IN 606 ± 89.7 vs. AN 255 ± 52.1; p < 0.05). These parameters were significantly increased in animals with necrotizing pancreatitis. CONCLUSION:
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Authors | Gabriel J Seifert, Philipp J Poxleitner, Sabine C Richter, Ulrich T Hopt, Uwe A Wittel |
Journal | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
(Pancreatology)
2014 May-Jun
Vol. 14
Issue 3
Pg. 179-85
ISSN: 1424-3911 [Electronic] Switzerland |
PMID | 24854613
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Copyright © 2014 IAP and EPC. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Cholagogues and Choleretics
- Fluoroquinolones
- Taurocholic Acid
- Moxifloxacin
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Cholagogues and Choleretics
- Escherichia coli Infections
(complications, drug therapy)
- Fluoroquinolones
(therapeutic use)
- Male
- Mice
- Mice, Inbred BALB C
- Moxifloxacin
- Pancreas
(microbiology, pathology)
- Pancreatitis, Acute Necrotizing
(chemically induced, drug therapy, microbiology, pathology)
- Taurocholic Acid
- Treatment Outcome
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