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Midline frontal cortex low-frequency activity drives subthalamic nucleus oscillations during conflict.

Abstract
Making the right decision from conflicting information takes time. Recent computational, electrophysiological, and clinical studies have implicated two brain areas as being crucial in assuring sufficient time is taken for decision-making under conditions of conflict: the medial prefrontal cortex and the subthalamic nucleus (STN). Both structures exhibit an elevation of activity at low frequencies (<10 Hz) during conflict that correlates with the amount of time taken to respond. This suggests that the two sites could become functionally coupled during conflict. To establish the nature of this interaction we recorded from deep-brain stimulation electrodes implanted bilaterally in the STN of 13 Parkinson's disease patients while they performed a sensory integration task involving randomly moving dots. By gradually increasing the number of dots moving coherently in one direction, we were able to determine changes in the STN associated with response execution. Furthermore, by occasionally having 10% of the dots move in the opposite direction as the majority, we were able to identify an independent increase in STN theta-delta activity triggered by conflict. Crucially, simultaneous midline frontal electroencephalographic recordings revealed an increase in the theta-delta band coherence between the two structures that was specific to high-conflict trials. Activity over the midline frontal cortex was Granger causal to that in STN. These results establish the cortico-subcortical circuit enabling successful choices to be made under conditions of conflict and provide support for the hypothesis that the brain uses frequency-specific channels of communication to convey behaviorally relevant information.
AuthorsBaltazar A Zavala, Huiling Tan, Simon Little, Keyoumars Ashkan, Marwan Hariz, Thomas Foltynie, Ludvic Zrinzo, Kareem A Zaghloul, Peter Brown
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci) Vol. 34 Issue 21 Pg. 7322-33 (May 21 2014) ISSN: 1529-2401 [Electronic] United States
PMID24849364 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Zavala et al.
Topics
  • Adult
  • Aged
  • Brain Mapping
  • Brain Waves (physiology)
  • Choice Behavior (physiology)
  • Conflict (Psychology)
  • Deep Brain Stimulation (methods)
  • Efferent Pathways (physiology)
  • Electroencephalography
  • Female
  • Frontal Lobe (physiology)
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parkinson Disease (physiopathology, therapy)
  • Subthalamic Nucleus (physiology)

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