Abstract | OBJECTIVE: METHODS: The first patient had been diagnosed with Cushing's disease due to a corticotroph pituitary microadenoma, declined neurosurgery, and was receiving pharmacological treatment with pasireotide. Her hypercortisolism was optimally controlled with a minimum dose. The second patient had undergone unilateral adrenalectomy due to a cortisol-secreting adenoma and was on tapering doses of hydrocortisone due to a suppressed corticotroph axis. Both patients presented with clinical, functional, and imaging features of DQT at a time when their endogenous glucocorticoid levels were very low. RESULTS: Oral glucocorticoid treatment was administered in both cases, resulting in prompt recovery. CONCLUSIONS: The incidence of DQT following the resolution of hypercortisolism, either medical or surgical, has not been previously described. The exact pathogenetic mechanism can only be speculated on. Perhaps the relative or absolute glucocorticoid deficiency after effective treatment of hypercortisolism alters immunologic responses and renders patients more vulnerable to thyrolytic processes.
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Authors | Zoe A Efstathiadou, Albana Sykja, Panagiotis Anagnostis, Athanasios Panagiotou, Marina Kita |
Journal | European thyroid journal
(Eur Thyroid J)
Vol. 3
Issue 1
Pg. 69-72
(Mar 2014)
ISSN: 2235-0640 [Print] England |
PMID | 24847470
(Publication Type: Journal Article)
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