Expression of carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) and its correlation with angiogenesis in gastric cancer.

Abstract

OBJECTIVE:

To examine the expression of carcinoembryonic antigen-related cell adhesion molecule 1(CEACAM1) and CD34 in gastric adenocarcinoma, and to investigate their relations with clinical pathology-related factors.

METHODS:

Immunohistochemistry (IHC) was used to analyze the expression of CEACAM1 and CD34, and micro-vessel density (MVD) marked by CD34 was calculated in 208 cases of human gastric adenocarcinoma and in 56 cases of normal human gastric tissues.

RESULTS:

There was no expression of CEACAM1 in normal gastric mucosa. However, all of the gastric adenocarcinoma tissues expressed CEACAM1 with cytoplasmic and/or membranous staining. CEACAM1 expression was classified as high and low (137/208 vs. 71/208, 65.9% vs. 34.1%), the CD34-MVD value was significantly different between the two groups (P<0.05). In addition, expressions of CEACAM1 and CD34 were significantly different from gastric adenocarcinoma to normal gastric tissues, respectively (P<0.05). High CEACAM1 expression and high MVD value were positively associated with lymph nodes metastasis and TNM stage, but negatively related to pathological grade (P<0.05). But they were irrelevant with tumor size, patients' age and gender (P>0.05).

CONCLUSIONS:

The up-regulation of CEACAM1 expression may participate in tumorous angiogenesis, especially high expression of CEACAM1 promoted its capability of invasion and metastasis.

• Authors: Jun-Feng Shi, Shi-Xin Xu, Ping He, Zhi-Hui Xi
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 210 Issue 8 Pg. 473-6 (Aug 2014) ISSN: 1618-0631 [Electronic] Germany
• PMID: 24846314 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier GmbH. All rights reserved.

Chemical References

• Antigens, CD
• Antigens, CD34
• CD66 antigens
• Cell Adhesion Molecules

Topics

• Adenocarcinoma (metabolism, pathology)
• Adult
• Aged
• Aged, 80 and over
• Antigens, CD (metabolism)
• Antigens, CD34 (metabolism)
• Cell Adhesion Molecules (metabolism)
• Female
• Gastric Mucosa (metabolism, pathology)
• Humans
• Male
• Middle Aged
• Neovascularization, Pathologic (metabolism, pathology)
• Stomach Neoplasms (metabolism, pathology)
• Up-Regulation