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Novel inhibitor of DNA ligase IV with a promising cancer therapeutic potential.

AuthorsAshwin Kotnis, Rita Mulherkar
JournalJournal of biosciences (J Biosci) Vol. 39 Issue 3 Pg. 339-40 (Jun 2014) ISSN: 0973-7138 [Electronic] India
PMID24845497 (Publication Type: Journal Article)
Chemical References
  • 5,6-bis(benzylideneamino)-2-mercaptopyrimidin-4-ol
  • LIG4 protein, human
  • Pyrimidines
  • Schiff Bases
  • DNA Ligases
  • DNA Ligase ATP
Topics
  • Animals
  • Cell Line, Tumor
  • DNA End-Joining Repair (drug effects)
  • DNA Ligase ATP
  • DNA Ligases (antagonists & inhibitors)
  • DNA Repair
  • Drug Evaluation, Preclinical
  • Humans
  • Mice
  • Neoplasms (drug therapy)
  • Pyrimidines (adverse effects, therapeutic use)
  • Schiff Bases (adverse effects, therapeutic use)

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