Abstract | OBJECTIVE: DESIGN: Observational intervention trial. PATIENTS AND MEASUREMENTS: RESULTS: Fasted FGF21 levels were elevated in T2DM subjects. Calorie restriction by either GB or VLCD lowered bile salt and FGF21 levels. In contrast, RYGB surgery was associated with elevated bile salt and FGF21 levels. CONCLUSIONS: Calorie restriction and RYGB have opposite effects on serum bile salt and FGF21 levels. Calorie restriction results in FGF21 approaching nonobese control levels, suggesting that this intervention is effective in reducing the "nutritional crisis" that appears to underly FGF21 elevation in obesity. FGF21 elevation after RYGB may contribute to the beneficial effect of this procedure.
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Authors | Mirjam A Lips, Gerrit H de Groot, Frits J Berends, Renee Wiezer, Bart A van Wagensveld, Dingeman J Swank, Arijan Luijten, Ko Willems van Dijk, Hanno Pijl, Peter L M Jansen, Frank G Schaap |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 81
Issue 6
Pg. 862-70
(Dec 2014)
ISSN: 1365-2265 [Electronic] England |
PMID | 24841294
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 John Wiley & Sons Ltd. |
Chemical References |
- FGF19 protein, human
- fibroblast growth factor 21
- Fibroblast Growth Factors
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Topics |
- Bariatric Surgery
(methods)
- Caloric Restriction
(methods)
- Diabetes Mellitus, Type 2
(blood, complications)
- Female
- Fibroblast Growth Factors
(blood)
- Gastric Bypass
(methods)
- Humans
- Middle Aged
- Obesity, Morbid
(blood, complications, therapy)
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