Salvaging hope: Is increasing NAD(+) a key to treating mitochondrial myopathy?

Abstract

Mitochondrial diseases can arise from mutations either in mitochondrial DNA or in nuclear DNA encoding mitochondrially destined proteins. Currently, there is no cure for these diseases although treatments to ameliorate a subset of the symptoms are being developed. In this issue of EMBO Molecular Medicine, Khan et al (2014) use a mouse model to test the efficacy of a simple dietary supplement of nicotinamide riboside to treat and prevent mitochondrial myopathies.

• Authors: Robert N Lightowlers, Zofia M A Chrzanowska-Lightowlers
• Journal: EMBO molecular medicine (EMBO Mol Med) Vol. 6 Issue 6 Pg. 705-7 (Jun 2014) ISSN: 1757-4684 [Electronic] England
• PMID: 24838280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Comment)

Chemical References

• Pyridinium Compounds
• nicotinamide-beta-riboside
• Vitamin B Complex
• Niacinamide

Topics

• Animals
• Male
• Mitochondria (drug effects)
• Mitochondrial Myopathies (drug therapy)
• Niacinamide (analogs & derivatives, therapeutic use)
• Pyridinium Compounds
• Vitamin B Complex (therapeutic use)