Inverse correlation of ribosomal protein S27A and multifunctional protein YB-1 in hepatocellular carcinoma.

Abstract

OBJECTIVE:

The detection of possible correlation between ribosomal protein RPS27A and multifunctional YB-1 expression in hepatocellular carcinoma (HCC).

DESIGN AND METHODS:

Tissue microarray slides containing totally 80 cores with 19 tissues of HCC, 1 tissue of hepatocholangiocarcinoma, 10 tissues of liver cirrhosis and 10 normal liver tissues in duplicates were analyzed for expression of RPS27A and YB-1 by immunohistochemistry.

RESULTS:

Among each of 10 LC and normal liver tissues all (100%) showed RPS27A positive expression but only 11 out of 19 HCC tissues (57.89%) showed RPS27A positive expression with significant difference compared (P<0.05) with both LC and normal tissues. We found positive expression of YB-1 in 17 tissues out of 19 HCC tissues (89.47%) but only 4 tissues out of each 10 LC as well as normal liver tissues showed positive expression with significant (P<0.01) difference compared to HCC tissues. A statistically significant inverse weak correlation (rho=-0.293) between YB-1 expression and RPS27A expression was found.

CONCLUSION:

The present investigation concludes that the ribosomal protein RPS27A was down-regulated in viral induced HCC patients. RPS27A expression was found to have a weak inverse correlation with overexpression of multifunctional protein YB-1 in HCC tissues. This study opens up a new window for YB-1-RPS27A axis in HCC.

• Authors: Vinoth Prasanna Gunasekaran, Mathan Ganeshan
• Journal: Clinical biochemistry (Clin Biochem) Vol. 47 Issue 13-14 Pg. 1262-4 (Sep 2014) ISSN: 1873-2933 [Electronic] United States
• PMID: 24833360 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

Chemical References

• RPS27a protein, human
• Ribosomal Proteins
• Ubiquitins
• Y-Box-Binding Protein 1
• YBX1 protein, human

Topics

• Carcinoma, Hepatocellular (genetics, metabolism)
• Down-Regulation (genetics)
• Humans
• Immunohistochemistry (methods)
• Liver (metabolism)
• Liver Cirrhosis (genetics)
• Liver Neoplasms (genetics, metabolism)
• Retrospective Studies
• Ribosomal Proteins (genetics)
• Ubiquitins (genetics)
• Y-Box-Binding Protein 1 (genetics, metabolism)