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Panton-Valentine Leukocidin-positive Staphylococcus aureus: a potentially significant pathogen in cystic fibrosis.

Abstract
Staphylococcus aureus is an important pathogen within the context of cystic fibrosis lung disease. Case reports have identified a strong association between the toxin Panton-Valentine Leukocidin (PVL) and lethal necrotizing pneumonia in healthy immunocompetent patients. PVL+ strains of Staphylococcus aureus have also been identified in patients with cystic fibrosis. We describe a further case of pneumonia in a patient with cystic fibrosis, and outline potential transmission of the organism from healthy family members to this patient. We review the evidence regarding the pathogenicity of PVL toxin with a special reference to patients with cystic fibrosis. We outline current concerns regarding the potential transmission of the organism and possible treatment strategies.
AuthorsPeter J Barry, Barbara J Isalska, Andrew M Jones
JournalPaediatric respiratory reviews (Paediatr Respir Rev) Vol. 15 Suppl 1 Pg. 22-5 (Jun 2014) ISSN: 1526-0550 [Electronic] England
PMID24832699 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Panton-Valentine leukocidin
Topics
  • Bacterial Toxins (biosynthesis)
  • Cystic Fibrosis (microbiology)
  • Exotoxins (biosynthesis)
  • Humans
  • Leukocidins (biosynthesis)
  • Male
  • Staphylococcal Infections (complications)
  • Staphylococcus aureus (metabolism)
  • Young Adult

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