Abstract |
Staphylococcus aureus is an important pathogen within the context of cystic fibrosis lung disease. Case reports have identified a strong association between the toxin Panton-Valentine Leukocidin (PVL) and lethal necrotizing pneumonia in healthy immunocompetent patients. PVL+ strains of Staphylococcus aureus have also been identified in patients with cystic fibrosis. We describe a further case of pneumonia in a patient with cystic fibrosis, and outline potential transmission of the organism from healthy family members to this patient. We review the evidence regarding the pathogenicity of PVL toxin with a special reference to patients with cystic fibrosis. We outline current concerns regarding the potential transmission of the organism and possible treatment strategies.
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Authors | Peter J Barry, Barbara J Isalska, Andrew M Jones |
Journal | Paediatric respiratory reviews
(Paediatr Respir Rev)
Vol. 15 Suppl 1
Pg. 22-5
(Jun 2014)
ISSN: 1526-0550 [Electronic] England |
PMID | 24832699
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Bacterial Toxins
- Exotoxins
- Leukocidins
- Panton-Valentine leukocidin
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Topics |
- Bacterial Toxins
(biosynthesis)
- Cystic Fibrosis
(microbiology)
- Exotoxins
(biosynthesis)
- Humans
- Leukocidins
(biosynthesis)
- Male
- Staphylococcal Infections
(complications)
- Staphylococcus aureus
(metabolism)
- Young Adult
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