Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth.

Abstract

OBJECTIVE:

The objective of the study was to determine whether pregnancies resulting in early preterm birth (PTB) (<30 weeks) were more likely than term pregnancies to have elevated midtrimester serum tumor necrosis factor alpha (TNF-α) levels combined with lipid patterns suggestive of hyperlipidemia.

STUDY DESIGN:

In 2 nested case-control samples drawn from California and Iowa cohorts, we examined the frequency of elevated midpregnancy serum TNF-α levels (in the fourth quartile [4Q]) and lipid patterns suggestive of hyperlipidemia (eg, total cholesterol, low-density-lipoproteins, or triglycerides in the 4Q, high-density lipoproteins in the first quartile) (considered independently and by co-occurrence) in pregnancies resulting in early PTB compared with those resulting in term birth (n = 108 in California and n = 734 in Iowa). Odds ratios (ORs) and 95% confidence intervals (CIs) estimated in logistic regression models were used for comparisons.

RESULTS:

Early preterm pregnancies were 2-4 times more likely than term pregnancies to have a TNF-α level in the 4Q co-occurring with indicators of hyperlipidemia (37.5% vs 13.9% in the California sample (adjusted OR, 4.0; 95% CI, 1.1-16.3) and 26.3% vs 14.9% in the Iowa sample (adjusted OR, 2.7; 95% CI, 1.1-6.3). No differences between early preterm and term pregnancies were observed when TNF-α or target lipid abnormalities occurred in isolation. Observed differences were not explicable to any maternal or infant characteristics.

CONCLUSION:

Pregnancies resulting in early PTB were more likely than term pregnancies to have elevated midpregnancy TNF-α levels in combination with lipid patterns suggestive of hyperlipidemia.

• Authors: Laura L Jelliffe-Pawlowski, Kelli K Ryckman, Bruce Bedell, Hugh M O'Brodovich, Jeffrey B Gould, Dierdre J Lyell, Kristi S Borowski, Gary M Shaw, Jeffrey C Murray, David K Stevenson
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 211 Issue 2 Pg. 141.e1-9 (Aug 2014) ISSN: 1097-6868 [Electronic] United States
• PMID: 24831886 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Mosby, Inc. All rights reserved.

Chemical References

• Lipids
• Tumor Necrosis Factor-alpha

Topics

• Adolescent
• Adult
• Body Mass Index
• California
• Case-Control Studies
• Female
• Humans
• Hyperlipidemias (blood, diagnosis)
• Infant, Newborn
• Iowa
• Lipids (blood)
• Pregnancy
• Pregnancy Complications (blood, diagnosis)
• Pregnancy Trimester, Second (blood)
• Premature Birth (blood)
• Tumor Necrosis Factor-alpha (blood)
• Young Adult