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Correlation between tumor size and blood volume in lung tumors: a prospective study on dual-energy gemstone spectral CT imaging.

Abstract
The purpose of this study was to investigate the relationship between tumor size and blood volume for patients with lung tumors, using dual-energy computed tomography (DECT) and a gemstone spectral imaging (GSI) viewer. During the period from March 2011 to March 2013, 50 patients with 57 medically inoperable lung tumors underwent DECT before stereotactic body radiotherapy (SBRT) of 50-60 Gy in 5-6 fractions. DECT was taken for pretreatment evaluation. The region-of-interest for a given spatial placement of the tumors was set, and averages for CT value, water density and iodine density were compared with tumor size. The average values for iodine density in tumors of ≤ 2 cm, 2-3 cm, and >3 cm maximum diameter were 24.7, 19.6 and 16.0 (100 µg/cm(3)), respectively. The average value of the iodine density was significantly lower in larger tumors. No significant correlation was detected between tumor size and average CT value or between tumor size and average water density. Both the average water density and the average CT value were affected by the amount of air in the tumor, but the average iodine density was not affected by air in the tumor. The average water density and the average CT value were significantly correlated, but the average iodine density and the average CT value showed no significant correlation. The blood volume of tumors can be indicated by the average iodine density more accurately than it can by the average CT value. The average iodine density as assessed by DECT might be a non-invasive and quantitative assessment of the radio-resistance ascribable to the hypoxic cell population in a tumor.
AuthorsMasahiko Aoki, Yoshihiro Takai, Yuichiro Narita, Katsumi Hirose, Mariko Sato, Hiroyoshi Akimoto, Hideo Kawaguchi, Yoshiomi Hatayama, Hiroyuki Miura, Shuichi Ono
JournalJournal of radiation research (J Radiat Res) Vol. 55 Issue 5 Pg. 917-23 (Sep 2014) ISSN: 1349-9157 [Electronic] England
PMID24829253 (Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
Copyright© The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
Topics
  • Absorptiometry, Photon (methods)
  • Blood Volume
  • Female
  • Humans
  • Lung Neoplasms (diagnostic imaging, physiopathology)
  • Male
  • Prospective Studies
  • Radiographic Image Interpretation, Computer-Assisted (methods)
  • Radiography, Dual-Energy Scanned Projection (methods)
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Statistics as Topic
  • Tomography, X-Ray Computed (methods)
  • Tumor Burden

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