Intravenous dezocine pretreatment reduces the incidence and intensity of myoclonus induced by etomidate.

Abstract

To evaluate the suppressive effect of intravenous dezocine on the incidence and severity of myoclonic movements induced by etomidate, a total of 80 patients, American Society of Anesthesiologists physical status I-II, were randomized into two equally sized groups (n = 40). These two groups were assigned to give either intravenous dezocine 0.1 mg/kg or a matching placebo (equal volume of 0.9% saline) 30 s before administration of etomidate. For anesthesia induction, 0.3 mg/kg etomidate was injected over a period of 1 min. One minute after etomidate administration, the severity of myoclonus was assessed. Pretreatment with dezocine significantly reduced both the incidence and intensity of myoclonus. These results demonstrate that intravenous dezocine 0.1 mg/kg 30 s prior to induction was effective in suppressing myoclonic movements in our patients.

• Authors: Zhifeng Lv, Zhifeng Lu, Jie Fang, Jianpo Zhu, Bing Liang, Fangkun Li, Suli Jiang, Ali Li, Zhifang Cheng, Tieli Dong
• Journal: Journal of anesthesia (J Anesth) Vol. 28 Issue 6 Pg. 944-7 (Dec 2014) ISSN: 1438-8359 [Electronic] Japan
• PMID: 24828848 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anesthetics, Intravenous
• Bridged Bicyclo Compounds, Heterocyclic
• Tetrahydronaphthalenes
• dezocine
• Etomidate

Topics

• Administration, Intravenous
• Adult
• Anesthetics, Intravenous (administration & dosage, adverse effects)
• Bridged Bicyclo Compounds, Heterocyclic (administration & dosage, pharmacology)
• Etomidate (administration & dosage, adverse effects)
• Female
• Humans
• Incidence
• Male
• Middle Aged
• Myoclonus (chemically induced, prevention & control)
• Tetrahydronaphthalenes (administration & dosage, pharmacology)