N-acetylglucosaminyltransferase III in human serum, and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patients.

Abstract

An N-acetylglucosaminyltransferase III which catalyzes the addition of N-acetylglucosamine through a beta 1-4 linkage (bisecting N-acetylglucosamine) to the beta-linked mannose of the trimannosyl core structure of N-linked oligosaccharides of glycoproteins was measured in human serum, and liver and hepatoma tissues. The enzyme activity in serum was significantly elevated in patients with hepatomas and liver cirrhosis, and the activity markedly decreased on the transcatheter arterial embolization treatment. High activities were also found in the hepatoma and cirrhotic liver tissues, indicating that the serum activity reflected the activity in the tissues. The assaying of the enzyme activity in serum appears to be useful for the detection and monitoring of primary hepatomas.

• Authors: K Ishibashi, A Nishikawa, N Hayashi, A Kasahara, N Sato, S Fujii, T Kamada, N Taniguchi
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 185 Issue 3 Pg. 325-32 (Dec 15 1989) ISSN: 0009-8981 [Print] Netherlands
• PMID: 2482796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• alpha-Fetoproteins
• Glucosyltransferases
• N-Acetylglucosaminyltransferases
• beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Topics

• Adult
• Carcinoma, Hepatocellular (blood, enzymology, therapy)
• Chronic Disease
• Embolization, Therapeutic
• Female
• Glucosyltransferases (analysis, blood)
• Hepatitis (blood, enzymology)
• Humans
• Liver (enzymology)
• Liver Cirrhosis (blood, enzymology)
• Liver Neoplasms (blood, enzymology, therapy)
• Male
• Middle Aged
• N-Acetylglucosaminyltransferases
• alpha-Fetoproteins (analysis)