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[Study on garlic oil combined with 5-FU induced apoptosis of adenoid cystic carcinoma cell line ACC-M].

AbstractOBJECTIVE:
To observe the effect of garlic oil combined with 5-FU induced apoptosis of adenoid cystic carcinoma cell line ACC-M.
METHOD:
Human salivary in adenoid cystic carcinoma cell line AC-M was cultured, divided into the experimental group (5-FU group, garlic oil group, garlic oil + 5-FU group) and the control group, to observe the growth activity of tumor cells by MTT methods; to analyse the changes of cell cycle and apoptosis rate by flow cytometry.
RESULT:
MTT experiments showed that 5-FU, garlic oil, garlic oil and 5-FU on ACC-M cells have inhibition in different concentration, with the increase of concentration and action time of the rise; Cell cycle analysis showed significant changes in flow cytometry. With the increase of concentration and the acting time, the G0/G1, phase of the cell ratio increased, S had no significant change, but G2/M phase cells decreased. Apoptosis rate display showed garlic oil combined with 5-FU induced apoptosis of ACC-M cells was significantly stronger than single group.
CONCLUSION:
Garlic oil can effectively induce the apoptosis of adenoid cystic carcinoma cell line ACC-M. The effect of garlic oil combined with 5-FU on ACC-M cells was stronger than the garlic oil, 5-FU used alone.
AuthorsFayin Wu, Hefeng Zhou, Zhiying Fan, Yawen Zhu, Yongye Li, Yukun Yao, Dan Ran
JournalLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 28 Issue 3 Pg. 175-7, 181 (Feb 2014) ISSN: 2096-7993 [Print] China
PMID24826454 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Allyl Compounds
  • Sulfides
  • allyl sulfide
  • Fluorouracil
Topics
  • Allyl Compounds (pharmacology)
  • Apoptosis (drug effects)
  • Carcinoma, Adenoid Cystic (pathology)
  • Cell Line, Tumor
  • Fluorouracil (pharmacology)
  • Humans
  • Sulfides (pharmacology)

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