Abstract | BACKGROUND: Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Mast cells (MCs) are located mainly at the host-environment interface where they function as sentinels. OBJECTIVE: Our goal was to study the role of MCs during pneumonia caused by S. pneumoniae. METHODS: RESULTS: The constitutive presence of tryptase-positive MCs was reduced in affected lungs from pneumonia patients. Kit(W-sh/W-sh) mice showed a prolonged survival during the first few days after median lethal dose (LD)100 and LD50 infection, while overall mortality did not differ from that in WT mice. Relative to WT mice, Kit(W-sh/W-sh) mice showed reduced bacterial counts with less bacterial dissemination to distant organs and less inflammation. Neither doxantrazole nor cromoglycate influenced antibacterial defense or inflammatory responses after airway infection with S. pneumoniae. CONCLUSIONS: MCs exhibit an unfavorable role in host defense during pneumococcal pneumonia by a mechanism independent of degranulation.
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Authors | Florry E van den Boogaard, Xanthe Brands, Joris J T H Roelofs, Regina de Beer, Onno J de Boer, Cornelis van 't Veer, Tom van der Poll |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 210
Issue 9
Pg. 1376-84
(Nov 01 2014)
ISSN: 1537-6613 [Electronic] United States |
PMID | 24823624
(Publication Type: Journal Article)
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Copyright | © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: [email protected]. |
Topics |
- Animals
- Bacterial Load
- Female
- Host-Pathogen Interactions
(immunology)
- Humans
- Lung
(microbiology, pathology)
- Male
- Mast Cells
(physiology)
- Mice
- Mice, Inbred C57BL
- Pneumonia, Pneumococcal
(immunology, microbiology, pathology)
- Streptococcus pneumoniae
(immunology)
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