Clinical effects of oseltamivir, zanamivir, laninamivir and peramivir on seasonal influenza infection in outpatients in Japan during the winter of 2012-2013.

Abstract

BACKGROUND:

The neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, laninamivir and peramivir are available in Japan. However, the selective use of NAIs for treating outpatients with influenza has not been clearly defined.

METHODS:

We assigned 191 patients with influenza to 4 groups, each treated with a different NAI, and then compared how long it took to alleviate fever and other symptoms and to eliminate the virus.

RESULTS:

Alleviation of fever occurred significantly sooner with peramivir than with either zanamivir (p = 0.0002) or oseltamivir (p = 0.0059), but was not significantly different from that with laninamivir (p = 0.0457; p < 0.0083). Other symptoms were also alleviated sooner by peramivir than by the other 3 NAIs.

CONCLUSIONS:

The ability of each NAI to alleviate influenza symptoms and fever varied. The appropriate use of NAIs requires further study.

• Authors: Yuji Takemoto, Teizaburo Asai, Itsuo Ikezoe, Takako Yano, Masahiro Ichikawa, Shogo Miyagawa, Jun Matsumoto
• Journal: Chemotherapy (Chemotherapy) Vol. 59 Issue 5 Pg. 373-8 ( 2013) ISSN: 1421-9794 [Electronic] Switzerland
• PMID: 24821568 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Acids, Carbocyclic
• Antiviral Agents
• Cyclopentanes
• Enzyme Inhibitors
• Guanidines
• Pyrans
• Sialic Acids
• Oseltamivir
• laninamivir
• Neuraminidase
• Zanamivir
• peramivir

Topics

• Acids, Carbocyclic
• Adult
• Aged
• Aged, 80 and over
• Antiviral Agents (therapeutic use)
• Child
• Child, Preschool
• Cyclopentanes (therapeutic use)
• Enzyme Inhibitors (therapeutic use)
• Female
• Guanidines (therapeutic use)
• Humans
• Infant
• Influenza, Human (drug therapy)
• Japan
• Male
• Middle Aged
• Neuraminidase (antagonists & inhibitors)
• Oseltamivir (therapeutic use)
• Outpatients
• Pyrans
• Sialic Acids
• Time Factors
• Treatment Outcome
• Young Adult
• Zanamivir (analogs & derivatives, therapeutic use)