Improvements in pain responsiveness in patients with fibrositis after successful treatment with amitriptyline.

Abstract

Thirty-six patients with fibrositis received low dose amitriptyline and placebo in a randomized double blind crossover study lasting 10 weeks. Amitriptyline was associated with significant changes on the outcome measures of pain, tender point sensitivity and patient assessment of well being. Clinically significant improvements for pain and tender point sensitivity and a statistically significant improvement in generalized pain responsiveness were found between patients who reported subjective improvement on amitriptyline and those who felt no change.

• Authors: R A Scudds, G A McCain, G B Rollman, M Harth
• Journal: The Journal of rheumatology. Supplement (J Rheumatol Suppl) Vol. 19 Pg. 98-103 (Nov 1989) ISSN: 0380-0903 [Print] Canada
• PMID: 2481743 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Amitriptyline

Topics

• Adult
• Amitriptyline (therapeutic use)
• Female
• Fibromyalgia (drug therapy)
• Humans
• Male
• Multivariate Analysis
• Pain Measurement
• Palliative Care
• Sensory Thresholds (drug effects)