The metabotropic glutamate receptor subtype 7 rs3792452 polymorphism is associated with the response to methylphenidate in children with attention-deficit/hyperactivity disorder.

Abstract

OBJECTIVE:

The purpose of this study was to investigate the association between the metabotropic glutamate receptor subtype 7 (mGluR7) gene (GRM7) polymorphism and treatment response to methylphenidate in Korean children with attention-deficit/hyperactivity disorder (ADHD).

METHODS:

We enrolled 175 medication-naïve children with ADHD in an open-label 8 week trial of methylphenidate. The participants were genotyped and evaluated using the Clinical Global Impressions (CGI) Scale and the parent version of the ADHD Rating Scale-IV (ADHD-RS) before and after treatment.

RESULTS:

After the 8 week course of methylphenidate, children with the GRM7 rs37952452 polymorphism G/A genotype had a more pronounced response rate to the treatment than did children with the G/G genotype according to the ADHD-RS scores (72.2% vs. 55.4%, respectively; p=0.011) and the more stringent standard of combined ADHD-RS and CGI-Improvement (CGI-I) scores (50.0% vs. 35.3%, respectively; p=0.044).

CONCLUSIONS:

The present study suggests that the GRM7 rs37952452 polymorphism may play a role in the treatment response to methylphenidate in children with ADHD. Further studies to evaluate the association between glutamate genes and treatment response to methylphenidate in children with ADHD, including a replication of our findings using a control or comparative group in a larger sample, are warranted.

• Authors: Subin Park, Bung-Nyun Kim, Soo-Churl Cho, Jae-Won Kim, Johanna Inhyang Kim, Min-Sup Shin, Hee-Jeong Yoo, Doug Hyun Han, Jae Hoon Cheong
• Journal: Journal of child and adolescent psychopharmacology (J Child Adolesc Psychopharmacol) Vol. 24 Issue 4 Pg. 223-7 (May 2014) ISSN: 1557-8992 [Electronic] United States
• PMID: 24815731 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Central Nervous System Stimulants
• Receptors, Metabotropic Glutamate
• metabotropic glutamate receptor 7
• Methylphenidate

Topics

• Adolescent
• Asian People
• Attention Deficit Disorder with Hyperactivity (drug therapy, genetics)
• Case-Control Studies
• Central Nervous System Stimulants (therapeutic use)
• Child
• Female
• Genotype
• Humans
• Male
• Methylphenidate (therapeutic use)
• Polymorphism, Single Nucleotide
• Psychiatric Status Rating Scales
• Receptors, Metabotropic Glutamate (genetics)
• Republic of Korea
• Treatment Outcome