Effects of selected antidiabetics on weight loss--a retrospective database analysis.

Abstract

AIMS:

In published studies metformin was often associated with weight loss in type 2 diabetes patients. Until now, no epidemiological studies have directly compared the effects of DPP-4 and GLP-1 versus metformin on weight loss. Our study is a comparison of sulfonylurea, DPP-4 and GLP-1 with metformin regarding body weight in type 2 diabetes patients.

METHODS:

Data from 2641 patients initiated therapy with either metformin, sulfonylurea, DPP-inhibitors or GLP-1 with baseline BMI >30 were retrospectively analyzed (Disease Analyzer Germany: 11/2008-10/2012). Comparison was performed for the weight change after 1 year of therapy compared with the last value prior to therapy. Differences between SU, DPP-4, GLP-1 versus metformin were estimated using regression model adjusted for age, gender, health insurance status, defined co-diagnoses and body weight at baseline.

RESULTS:

In absolute values, metformin patients lost an average of 2.6 kg, subjects treated with SU gained 0.3 kg, body weight in the DPP-4 group decreased by 1.8 kg and GLP-1 patients lost 3.3 kg in body weight after 1 year. After adjustment for other variables, comparisons with metformin revealed the following results: SU +3.4 kg (p < 0.001), DPP-4 +1.0 kg (p = 0.003) and GLP-1 -0.4 kg (p = 0.589).

CONCLUSION:

Our study showed that GLP-1 treatment was comparable to metformin regarding the weight reduction, while sulfonylurea and DPP-4 are inferior in this regard.

• Authors: Karel Kostev, Juliana Rex, Timo Rockel, Christina Heilmaier
• Journal: Primary care diabetes (Prim Care Diabetes) Vol. 9 Issue 1 Pg. 74-7 (Feb 2015) ISSN: 1878-0210 [Electronic] England
• PMID: 24815575 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Dipeptidyl-Peptidase IV Inhibitors
• Hypoglycemic Agents
• Sulfonylurea Compounds
• Glucagon-Like Peptide 1

Topics

• Aged
• Databases, Factual
• Diabetes Mellitus, Type 2 (drug therapy)
• Dipeptidyl-Peptidase IV Inhibitors (therapeutic use)
• Female
• Glucagon-Like Peptide 1 (therapeutic use)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Male
• Middle Aged
• Retrospective Studies
• Sulfonylurea Compounds (therapeutic use)
• Time Factors
• Treatment Outcome
• Weight Loss (drug effects)