Patch testing with a textile dye mix--a multicentre study.

Abstract

BACKGROUND:

Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series.

OBJECTIVES:

To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology clinics in various countries.

PATIENTS/MATERIALS/METHODS:

Two thousand nine hundred and seven consecutive dermatitis patients at 12 dermatology clinics representing nine countries were tested with a TDM at 6.6%, consisting of Disperse Blue 35, Disperse Yellow 3, Disperse Orange 1 and 3, and Disperse Red 1 and 17, all at 1.0%, and Disperse Blue 106 and Disperse Blue 124, each at 0.3%, provisionally included in the baseline series. Eighty-seven per cent of the patients allergic to the TDM were also tested with the eight separate dyes.

RESULTS:

Contact allergy to TDM was found in 108 patients (3.7%). The frequency of contact allergy varied from 2.1% to 6.9% in different centres. Simultaneous reactivity to p-phenylenediamine was found in 57 of the TDM-positive patients (53%). The most frequent dye allergen among the TDM-positive patients was Disperse Orange 3. The contact allergy could have explained or contributed to the dermatitis in approximately one-third of the patients for whom clinical relevance of the TDM contact allergy was recorded.

CONCLUSIONS:

The TDM should be considered for inclusion in the European baseline series.

• Authors: Kristina Ryberg, Tove Agner, Klaus E Andersen, Andreas Bircher, Thomas Diepgen, Caterina Foti, Ana Giménez-Arnau, Margarida Gonçalo, An Goossens, Jeanne D Johansen, Christophe Le Coz, Howard I Maibach, Magnus Bruze
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 71 Issue 4 Pg. 215-23 (Oct 2014) ISSN: 1600-0536 [Electronic] England
• PMID: 24815318 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Azo Compounds
• Phenylenediamines
• Disperse Orange 3
• N-isopropyl-N-phenyl-4-phenylenediamine
• Benzocaine
• 4-phenylenediamine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Azo Compounds (adverse effects)
• Benzocaine (adverse effects)
• Child
• Child, Preschool
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Humans
• Male
• Middle Aged
• Patch Tests
• Phenylenediamines (adverse effects)
• Textiles (adverse effects)
• Young Adult