HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

In silico analysis of expression pattern of a Wnt/β-catenin responsive gene ANLN in gastric cancer.

Abstract
Actin-binding protein anillin (ANLN) is primarily involved in the cytokinesis and known to be dysregulated in many cancers including gastric cancer (GC). However, the regulation and clinical significance of ANLN in GC are far less clear. In the present study, we aimed to investigate the clinical significance and possible regulators of ANLN in GC. We have identified the Wnt/β-catenin associated regulation of ANLN by analyzing the in vitro perturbed β-catenin mRNA expression profiles. Investigating the gastric tumors from publicly available genome-wide mRNA expression profiles, we have identified the over expression of ANLN in gastric tumors. Association between ANLN expression and clinical characteristics of GC showed elevated expression in intestinal type GC. Performing a single sample prediction method across GC mRNA expression profiles, we have identified the over expression of ANLN in proliferative type gastric tumors compared to the invasive and metabolic type gastric tumors. In silico pathway prediction analysis revealed the association between Wnt/β-catenin signaling and ANLN expression in gastric tumors. Our results highlight that expression of a Wnt/β-catenin responsive gene ANLN in GC is a molecular predictor of intestinal and proliferative type gastric tumors.
AuthorsNarayanan Sathiya Pandi, Muthaiah Manimuthu, Palaniswamy Harunipriya, Manikandan Murugesan, George Virumaandi Asha, Suriliyandi Rajendran
JournalGene (Gene) Vol. 545 Issue 1 Pg. 23-9 (Jul 15 2014) ISSN: 1879-0038 [Electronic] Netherlands
PMID24809965 (Publication Type: Journal Article)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • ANLN protein, human
  • CTNNB1 protein, human
  • Contractile Proteins
  • ESR1 protein, human
  • Estrogen Receptor alpha
  • Microfilament Proteins
  • anillin
  • beta Catenin
Topics
  • Cell Proliferation
  • Computer Simulation
  • Contractile Proteins (genetics, metabolism)
  • Estrogen Receptor alpha (genetics, metabolism)
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Intestinal Neoplasms (genetics, pathology)
  • Microfilament Proteins (genetics)
  • Stomach Neoplasms (genetics, pathology)
  • Wnt Signaling Pathway
  • beta Catenin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: