Radiation-induced dedifferentiated chondrosarcoma with orbital invasion.

Abstract

PURPOSE:

To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment.

METHODS:

Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature.

RESULTS:

The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia.

CONCLUSIONS:

These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.

• Authors: Brett W Davies, Christina R Prescott, Sherif A Said, John Campana, Flávia A Attié-Castro, Antonio Augusto Velasco E Cruz, Vikram D Durairaj
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2014 May-Jun Vol. 30 Issue 3 Pg. 205-8 ISSN: 1537-2677 [Electronic] United States
• PMID: 24807535 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Cobalt Radioisotopes

Topics

• Adult
• Cell Dedifferentiation
• Chondrosarcoma (diagnosis, etiology)
• Cobalt Radioisotopes (adverse effects)
• Facial Bones (pathology)
• Fatal Outcome
• Female
• Fibrous Dysplasia of Bone (radiotherapy)
• Humans
• Infant
• Magnetic Resonance Imaging
• Male
• Neoplasm Invasiveness
• Neoplasms, Radiation-Induced (diagnosis, etiology)
• Orbital Neoplasms (diagnostic imaging, pathology)
• Retinal Neoplasms (radiotherapy)
• Retinoblastoma (radiotherapy)
• Skull Neoplasms (diagnosis, etiology)
• Tomography, X-Ray Computed