[Post-injection delirium/sedation syndrome following injection of olanzapine pamoate: a new syndrome in emergency psychiatry].

The PDSS is a potential side-effect of the intramuscular injection of olanzapine pamoate. We saw the typical symptoms develop in a 46-year-old man 4 hours after the injection. The syndrome is caused by a toxic concentration of olanzapine, and is possibly the result of the direct injection of the substance in the bloodstream. The most important measures that can be taken to prevent such an emergency are: a careful injection procedure, a 3-hour observation period following the injection and good counselling of the patient and his family. The treatment is conservative.
AuthorsK Buts, J Van Hecke
JournalTijdschrift voor psychiatrie (Tijdschr Psychiatr) Vol. 56 Issue 4 Pg. 273-6 ( 2014) ISSN: 0303-7339 [Print] Netherlands
Vernacular TitlePostinjectiedelirium/sedatiesyndroom na injectie van olanzapinepamoaat: een nieuw syndroom in de spoedeisende psychiatrie.
PMID24807388 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Delayed-Action Preparations
  • Benzodiazepines
  • olanzapine
  • Antipsychotic Agents (administration & dosage, adverse effects)
  • Benzodiazepines (administration & dosage, adverse effects)
  • Delayed-Action Preparations
  • Delirium (chemically induced, diagnosis)
  • Drug Overdose (etiology, metabolism)
  • Drug-Related Side Effects and Adverse Reactions (diagnosis, metabolism)
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Schizophrenia (drug therapy)
  • Syndrome
  • Treatment Outcome

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