Adjuvant single-fraction radiotherapy is safe and effective for intractable keloids.

Abstract

The aim of this study was to assess the feasibility and efficacy of high-dose, single-fraction electron beam radiotherapy for therapy-resistant keloids. Before 2010, intractable keloids were treated at our institution with post-operative irradiation of 6-15 Gy in 3-5 fractionations. For convenience and cost effectiveness, we have changed our treatment protocol to high-dose single-fraction radiotherapy. A total of 12 patients with 16 keloid lesions were treated from January 2010 to January 2013 in our department. A 10-Gy dose of electron irradiation was given within 72 h of the surgical excision. The mean follow-up period was 20 months. Treatments were well tolerated, and there was no recurrence in any of the patients. Severe adverse effects were not observed. Surgical excision of the keloid, followed by immediate, single-fraction, high-dose radiotherapy, is both safe and effective in preventing recurrence of therapy-resistant keloids.

• Authors: Changhoon Song, Hong-Gyun Wu, Hak Chang, Il Han Kim, Sung W Ha
• Journal: Journal of radiation research (J Radiat Res) Vol. 55 Issue 5 Pg. 912-6 (Sep 2014) ISSN: 1349-9157 [Electronic] England
• PMID: 24801475 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

Topics

• Adult
• Chronic Disease
• Combined Modality Therapy
• Dose Fractionation, Radiation
• Female
• Humans
• Keloid (pathology, therapy)
• Male
• Middle Aged
• Radiodermatitis (etiology, prevention & control)
• Radiotherapy, Adjuvant (adverse effects, methods)
• Radiotherapy, Conformal (adverse effects, methods)
• Treatment Outcome