Comparative effectiveness of intravenous immunoglobulin from different manufacturing processes on Kawasaki disease.

Abstract

BACKGROUND:

The comparative effectiveness of intravenous immunoglobulin (IVIG) for Kawasaki disease was regarded as inconclusive in the international guidelines. However, several new evidences have been published in recent years.

DATA SOURCES:

A literature search of PubMed was conducted using key words of "Kawasaki disease or mucocutaneous lymph node syndrome" and "immunoglobulin" in combination. Only original articles published after 2004 were selected. A total of 813 papers were found in PubMed. These papers were screened manually by their titles and abstracts.

RESULTS:

Patients treated with IVIG prepared by betapropiolactonation might have worse outcome (a higher non-responsive rate in one report and a higher rate of coronary aneurysm in two reports). Storage of IVIG in acidic solution might be correlated with a higher rate of coronary aneurysm (two reports).

CONCLUSIONS:

Different processes of preparation and conditions of preservation of IVIG may have profound effects on its clinical effectiveness. Randomized controlled studies are needed to further elucidate this issue.

• Authors: Ming-Chih Lin
• Journal: World journal of pediatrics : WJP (World J Pediatr) Vol. 10 Issue 2 Pg. 114-8 (May 2014) ISSN: 1867-0687 [Electronic] Switzerland
• PMID: 24801230 (Publication Type: Journal Article, Review)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Child
• Comparative Effectiveness Research
• Drug Compounding
• Humans
• Immunoglobulins, Intravenous (chemistry, therapeutic use)
• Mucocutaneous Lymph Node Syndrome (drug therapy)