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An overview of fotemustine in high-grade gliomas: from single agent to association with bevacizumab.

Abstract
Fotemustine is a third-generation nitrosourea showing efficacy in various types of tumors such as melanoma and glioma. We reviewed the most important studies on fotemustine treatment in glioma patients analyzing its pharmacological profile and its activity and safety. Fotemustine was used as single agent or in association with new targeted drugs such as bevacizumab; fotemustine was used both as first-line chemotherapy before temozolomide era and in refractory-temozolomide patients during temozolomide era. Finally, analyzing and comparing the activity and safety of fotemustine alone or in combination with bevacizumab versus other nitrosoureas such as lomustine, we may suggest that the combination treatment with bevacizumab and fotemustine may be active and tolerable in patients with high grade gliomas.
AuthorsGiuseppe Lombardi, Patrizia Farina, Alessandro Della Puppa, Diego Cecchin, Ardi Pambuku, Luisa Bellu, Vittorina Zagonel
JournalBioMed research international (Biomed Res Int) Vol. 2014 Pg. 698542 ( 2014) ISSN: 2314-6141 [Electronic] United States
PMID24800248 (Publication Type: Journal Article, Review)
Chemical References
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents
  • Nitrosourea Compounds
  • Organophosphorus Compounds
  • Bevacizumab
  • fotemustine
Topics
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Monoclonal, Humanized (administration & dosage, therapeutic use)
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Bevacizumab
  • Brain Neoplasms (drug therapy)
  • Drug Therapy, Combination
  • Glioma (drug therapy)
  • Humans
  • Middle Aged
  • Nitrosourea Compounds (administration & dosage, therapeutic use)
  • Organophosphorus Compounds (administration & dosage, therapeutic use)
  • Young Adult

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