Chemokines and chemokine receptors required for optimal responses to anticancer chemotherapy.

Abstract

Depending on tumor type, stage and immunological contexture, the inhibition of chemokines or their receptors may yield positive or deleterious effects on disease progression. We have recently demonstrated in several murine models of anthracycline-based chemotherapy that the inhibition of chemokine (C-C motif) ligand 2 (CCL2) or chemokine (C-C motif) receptor 2 (CCR2) may impair the elicitation of anticancer immune responses that contribute to therapeutic success.

• Authors: Yuting Ma, Sandy Adjemian, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer
• Journal: Oncoimmunology (Oncoimmunology) Vol. 3 Issue 1 Pg. e27663 (Jan 01 2014) ISSN: 2162-4011 [Print] United States
• PMID: 24800170 (Publication Type: Journal Article)