Gastric cancer patients less than 50 years of age exhibit significant downregulation of E-cadherin and CDX2 compared to older reference populations.

Abstract

PURPOSE:

There is an increasing need to identify molecular markers, which can be used to prognosticate patient populations in gastric cancer. Whereas a significant number have been identified, very few have been characterized in the context of their ability to discriminate between young and old age groups in which a survival difference clearly exists.

MATERIAL/METHODS:

In this study, using immunohistochemistry, we evaluated three markers with proven involvement in gastric cancer. The p53 tumor suppressor, the cell adhesion glycoprotein epithelial cadherin (CDH1) and the caudal-related homeobox transcription factor (CDX2) all of these have important roles in the aetiopathogenesis and/or progression of gastric cancer.

RESULTS:

After adjustments for TNM stage, tumor grade, histopathological characteristics (Lauren classification), we found significant differences in the expression of these proteins, particularly E-cadherin and CDX2 between young and elderly patients. However, these differences did not amount to a significant difference in survival.

CONCLUSIONS:

This study demonstrates that the protein expression of p53, CDH1 and CDX2 significantly discriminates young patients with gastric cancer who have a better prognostic outlook from older patients, but this difference in expression does not contribute to a survival benefit.

• Authors: Claus Wilhelm Schildberg, Mohammed Abba, Susanne Merkel, Abbas Agaimy, Arno Dimmler, Anne Schlabrakowski, Roland Croner, Jörg Hendrik Leupold, Werner Hohenberger, Heike Allgayer
• Journal: Advances in medical sciences (Adv Med Sci) Vol. 59 Issue 1 Pg. 142-6 (Mar 2014) ISSN: 1898-4002 [Electronic] Netherlands
• PMID: 24797991 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2014 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Chemical References

• Biomarkers, Tumor
• CDX2 Transcription Factor
• CDX2 protein, human
• Cadherins
• Homeodomain Proteins

Topics

• Biomarkers, Tumor (metabolism)
• CDX2 Transcription Factor
• Cadherins (metabolism)
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Germany (epidemiology)
• Homeodomain Proteins (metabolism)
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Reference Values
• Retrospective Studies
• Stomach Neoplasms (epidemiology, metabolism, mortality)
• Survival Rate
• Tissue Array Analysis