Abstract | BACKGROUND: METHODS: In a group of patients with psoriasis (19), treated with Goeckerman regimen (GR), we evaluated their level of CN, level of chromosomal aberration in peripheral lymphocytes (CA), level of urinary 1-hydroxypyrene (1-OHP) and their value of Psoriasis Area and Severity Index (PASI). RESULTS: Following the treatment, the serum level of CN and urinary level of 1-OHP (p<0.05) were significantly increased (p<0.01). We found significant correlation between CN and urinary level of 1-OHP after GR (r=0.57; p<0.05). Immediately after the treatment we found significantly increased total numbers of abnormal chromosomes (ABB; p<0.01) and structurally abnormal chromosomes (SAB; p<0.05). CONCLUSIONS: We found slightly (but statistically significant) elevated level of circulating biomarkers of cell death ( nucleosomes) in patients with plaque psoriasis treated with GR (PAHs, UV radiation). We suppose that elevated level of CN is a result of combination of the positive effects of GR and its weak genotoxic effect (mainly PAHs). Conclusions are supported by significant correlation between CN and urinary level of 1-OHP after GR and significantly elevated level of CA after GR (Tab. 2, Fig. 1, Ref. 28).
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Authors | D Ranna, C Andrys, J Krejsek, K Hamakova, J Kremlacek, Z Fiala, P Borsky, L Borska |
Journal | Bratislavske lekarske listy
(Bratisl Lek Listy)
Vol. 115
Issue 4
Pg. 229-32
( 2014)
ISSN: 0006-9248 [Print] Slovakia |
PMID | 24797598
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Nucleosomes
- Pyrenes
- 1-hydroxypyrene
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Topics |
- Biomarkers
(blood)
- Cell Death
(physiology)
- Humans
- Nucleosomes
(metabolism)
- Psoriasis
(blood, therapy)
- Pyrenes
(urine)
- Ultraviolet Therapy
(methods)
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