SAICAR binding activates PKM2 protein kinase activity. -

SAICAR binding activates PKM2 protein kinase activity.

Abstract	SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation.
Authors
Journal	Cancer discovery (Cancer Discov) Vol. 4 Issue 5 Pg. OF20 (May 2014) ISSN: 2159-8290 [Electronic] United States
PMID	24795025 (Publication Type: Journal Article)
Chemical References	Carrier Proteins Membrane Proteins Ribonucleotides Thyroid Hormones thyroid hormone-binding proteins Aminoimidazole Carboxamide SAICAR
Topics	Aminoimidazole Carboxamide (analogs & derivatives, chemistry, metabolism) Carrier Proteins (chemistry, metabolism) Cell Cycle Cell Proliferation Humans Membrane Proteins (chemistry, metabolism) Neoplasms (metabolism) Phosphorylation Ribonucleotides (chemistry, metabolism) Signal Transduction Thyroid Hormones (chemistry, metabolism)

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