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Serum alpha-fetoprotein subfractions identified by Ricinus communis agglutinin I in hepatic malignancies, yolk sac tumor, benign hepatic diseases, and fetal stage.

Abstract
Using Ricinus communis agglutinin I (RCA-I) affinity crossed-line immunoelectrophoresis, alpha-fetoprotein (AFP) subfractions were studied in sera from patients with primary hepatic cancer (PHC), hepatic metastasis of gastric cancer (HMGC), yolk sac tumor (YST), acute or chronic hepatitis or hepatic cirrhosis. Fetal AFP subfractions were also examined in amniotic fluids or in culture fluids of fetal tissues. RCA-I non-reactive subfraction was commonly found in PHC, HMGC, YST, benign hepatic diseases, and fetal stage. RCA-I weakly reactive (WR) or strongly reactive (SR) subfraction was noted only in malignant diseases. RCA-I has a specific affinity to terminal galactose in oligosaccharide, and the presence of sialic acid on galactose residue(s) inhibits the affinity with RCA-I. Therefore, common AFP subfraction non-reactive with RCA-I was assumed to be galactosialyl form, while RCA-I WR and SR subfractions found only in malignancies were monogalactosyl and digalactosyl, respectively. Clinically this approach to detect the RCA-I WR or SR subfraction facilitates a differential diagnosis of AFP-producing malignancies and benign conditions.
AuthorsT Ishiguro, Y Takahashi
JournalDisease markers (Dis Markers) 1989 Oct-Dec Vol. 7 Issue 4 Pg. 239-45 ISSN: 0278-0240 [Print] United States
PMID2479498 (Publication Type: Journal Article)
Chemical References
  • Lectins
  • Plant Lectins
  • Ricinus communis agglutinin-1
  • alpha-Fetoproteins
Topics
  • Amniotic Fluid (analysis)
  • Fetus (metabolism)
  • Gastric Mucosa (metabolism)
  • Gestational Age
  • Hepatitis (blood)
  • Humans
  • Immunoelectrophoresis, Two-Dimensional
  • Intestine, Small (embryology, metabolism)
  • Lectins
  • Liver (embryology, metabolism)
  • Liver Cirrhosis (blood)
  • Liver Diseases (blood)
  • Liver Neoplasms (blood)
  • Mesonephroma (blood)
  • Plant Lectins
  • Stomach (embryology)
  • Yolk Sac (metabolism)
  • alpha-Fetoproteins (isolation & purification)

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