[Advance in studies on traditional Chinese medicine on Abeta's scavenging effect].

Abstract

Aggregation and accumulation of beta-amyloid peptide (Abeta) in brain tissues contribute to the pathogenesis of Alzheimer's disease. Therefore, the promotion of Abeta clearance is one of the key targets for preventing and treatment Alzheimer's disease. Studies proved that some traditional Chinese medicine (TCM) compounds and extracts could impact the activity of degrading enzyme in amyloid peptide, the transport of hemato encephalic barrier and the phagocytosis of microglial cells, promote Abeta clearance, and improve learning and memory of animal models with Alzheimer's disease. In this review, we made an summary for the relations between Abeta and Alzheimer's disease, the Abeta clearance mechanism and the clearance effect of traditional Chinese medicines.

• Authors: Peng Li, Fu-Kai Huang, Chun Yang, Xin Zhou, Yu-Feng Liu, Bin Yan, Xiao-Ping Song, Ya-Li Liu, Lin Yuan
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 38 Issue 23 Pg. 4020-3 (Dec 2013) ISSN: 1001-5302 [Print] China
• PMID: 24791480 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Amyloid beta-Peptides

Topics

• Alzheimer Disease (drug therapy, metabolism, pathology)
• Amyloid beta-Peptides (chemistry, metabolism)
• Animals
• Blood-Brain Barrier (drug effects, metabolism)
• Humans
• Medicine, Chinese Traditional (methods)
• Microglia (drug effects, metabolism)
• Protein Multimerization (drug effects)