Abstract | PURPOSE: PATIENTS AND METHODS: A total of 36 previously untreated primary open-angle glaucoma patients were enrolled in this 5-year study. Patients underwent an untreated 24-hour IOP evaluation. Subsequently all patients were assigned to topical therapy with travoprost 0.004% eye-drops preserved with benzalkonium chloride ( Travatan, Alcon Laboratories Inc., Fort Worth, TX) administered once in the evening (8:00 PM) in both eyes. All patients were then scheduled for a 24-hour IOP assessment approximately 12 months after the baseline visit. This schedule of follow-up was maintained for the whole duration of the trial. The predetermined range of target IOP reduction selected in this cohort of patients ranged between 20% and 30%. RESULTS: A total of 34 patients completed all phases of the investigation. The mean survival time was 57.3±2.0 months and the cumulative survival rate was 0.82±0.6 at 60 months. Travoprost reduced the mean 24-hour IOP from 23.4±1.7 mm Hg at baseline to 16.8±2.4 mm Hg (28.4%), 16.8±2.5 mm Hg (28.1%), 16.8±2.4 mm Hg (28.5%), 16.7±2.5 mm Hg (28.6%), and 16.9±2.4 mm Hg (27.8%), respectively at the end of the first, second, third, fourth, and fifth year follow-up. No drug-related serious adverse events were registered during the study. CONCLUSIONS:
|
Authors | Ivano Riva, Andreas Katsanos, Irene Floriani, Elena Biagioli, Anastasios G P Konstas, Marco Centofanti, Luciano Quaranta |
Journal | Journal of glaucoma
(J Glaucoma)
2014 Oct-Nov
Vol. 23
Issue 8
Pg. 535-40
ISSN: 1536-481X [Electronic] United States |
PMID | 24786103
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Antihypertensive Agents
- Ophthalmic Solutions
- Cloprostenol
- Travoprost
|
Topics |
- Aged
- Aged, 80 and over
- Antihypertensive Agents
(administration & dosage)
- Cloprostenol
(administration & dosage, analogs & derivatives)
- Female
- Glaucoma, Open-Angle
(drug therapy, physiopathology)
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Ophthalmic Solutions
- Prospective Studies
- Travoprost
|