HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population.

AbstractOBJECTIVE:
To describe the human papillomavirus (HPV) genotype distribution in invasive vaginal cancers diagnosed before the introduction of the HPV vaccine and evaluate if survival differed by HPV status.
METHODS:
Four population-based registries and three residual tissue repositories provided formalin-fixed, paraffin-embedded tissue from microscopically confirmed primary vaginal cancer cases diagnosed between 1994 and 2005 that were tested by L1 consensus polymerase chain reaction with type-specific hybridization in a central laboratory. Clinical, demographic, and all-cause survival data were assessed by HPV status.
RESULTS:
Sixty cases of invasive vaginal cancer were included. Human papillomavirus was detected in 75% (45) and 25% (15) were HPV-negative. HPV 16 was most frequently detected (55% [33/60]) followed by HPV 33 (18.3% [11/60]). Only one case was positive for HPV 18 (1.7%) Multiple types were detected in 15% of the cases. Vaginal cancers in women younger than 60 years were more likely to be HPV 16- or HPV 18-positive (HPV 16 and 18) than older women, 77.3% compared with 44.7% (P=.038). The median age at diagnosis was younger in the HPV 16 and 18 (59 years) group compared with other HPV-positive (68 years) and no HPV (77 years) (P=.003). The HPV distribution did not significantly vary by race or ethnicity or place of residence. The 5-year unadjusted all-cause survival was 57.4% for women with HPV-positive vaginal cancers compared with 35.7% among those with HPV-negative tumors (P=.243).
CONCLUSION:
Three fourths of all vaginal cancers in the United States had HPV detected, much higher than previously found, and 57% could be prevented by current HPV vaccines.
AuthorsAbdulrahman K Sinno, Mona Saraiya, Trevor D Thompson, Brenda Y Hernandez, Marc T Goodman, Martin Steinau, Charles F Lynch, Wendy Cozen, Maria Sibug Saber, Edward S Peters, Edward J Wilkinson, Glenn Copeland, Claudia Hopenhayn, Meg Watson, Christopher Lyu, Elizabeth R Unger
JournalObstetrics and gynecology (Obstet Gynecol) Vol. 123 Issue 4 Pg. 817-21 (Apr 2014) ISSN: 1873-233X [Electronic] United States
PMID24785610 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Topics
  • Adenocarcinoma (genetics)
  • Alphapapillomavirus (genetics)
  • Carcinoma, Squamous Cell (genetics)
  • Female
  • Genotype
  • Human papillomavirus 16 (isolation & purification)
  • Humans
  • Kaplan-Meier Estimate
  • Middle Aged
  • Proportional Hazards Models
  • Registries
  • Vaginal Neoplasms (mortality, pathology, virology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: