Abstract | OBJECTIVE: To describe the human papillomavirus (HPV) genotype distribution in invasive vaginal cancers diagnosed before the introduction of the HPV vaccine and evaluate if survival differed by HPV status. METHODS: Four population-based registries and three residual tissue repositories provided formalin-fixed, paraffin-embedded tissue from microscopically confirmed primary vaginal cancer cases diagnosed between 1994 and 2005 that were tested by L1 consensus polymerase chain reaction with type-specific hybridization in a central laboratory. Clinical, demographic, and all-cause survival data were assessed by HPV status. RESULTS: Sixty cases of invasive vaginal cancer were included. Human papillomavirus was detected in 75% (45) and 25% (15) were HPV-negative. HPV 16 was most frequently detected (55% [33/60]) followed by HPV 33 (18.3% [11/60]). Only one case was positive for HPV 18 (1.7%) Multiple types were detected in 15% of the cases. Vaginal cancers in women younger than 60 years were more likely to be HPV 16- or HPV 18-positive (HPV 16 and 18) than older women, 77.3% compared with 44.7% (P=.038). The median age at diagnosis was younger in the HPV 16 and 18 (59 years) group compared with other HPV-positive (68 years) and no HPV (77 years) (P=.003). The HPV distribution did not significantly vary by race or ethnicity or place of residence. The 5-year unadjusted all-cause survival was 57.4% for women with HPV-positive vaginal cancers compared with 35.7% among those with HPV-negative tumors (P=.243). CONCLUSION: Three fourths of all vaginal cancers in the United States had HPV detected, much higher than previously found, and 57% could be prevented by current HPV vaccines.
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Authors | Abdulrahman K Sinno, Mona Saraiya, Trevor D Thompson, Brenda Y Hernandez, Marc T Goodman, Martin Steinau, Charles F Lynch, Wendy Cozen, Maria Sibug Saber, Edward S Peters, Edward J Wilkinson, Glenn Copeland, Claudia Hopenhayn, Meg Watson, Christopher Lyu, Elizabeth R Unger |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 123
Issue 4
Pg. 817-21
(Apr 2014)
ISSN: 1873-233X [Electronic] United States |
PMID | 24785610
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Adenocarcinoma
(genetics)
- Alphapapillomavirus
(genetics)
- Carcinoma, Squamous Cell
(genetics)
- Female
- Genotype
- Human papillomavirus 16
(isolation & purification)
- Humans
- Kaplan-Meier Estimate
- Middle Aged
- Proportional Hazards Models
- Registries
- Vaginal Neoplasms
(mortality, pathology, virology)
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