Abstract |
This study was intended to design an orally disintegrating tablet (ODT) formulation that can mask the extremely bitter and metallic taste of phencynonate HCl by novel ion-exchange resins. The drug-resin complexes (DRCs) were prepared and characterized by scanning electron microscopy, X-ray powder diffraction and differential scanning calorimetry. In vitro properties (dissolution, wetting time and disintegration time) and in vivo behavior (disintegration time and taste-masking effect) in healthy volunteers of the prepared ODTs were also investigated. The drug was changed from the crystal structure to the amorphous form in the DRC. Compared with commercial tablets, the in vitro and in vivo disintegration of optimized DRC-loaded ODTs with a drug-resin ratio of 1:1 was greatly improved and better palatability with a low bitterness index (0.33) was obtained. The current DRC-loaded ODT could promise a good way to mask the unpleasant taste of certain drugs and accordingly improve the patient compliance.
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Authors | Zhenzhong Ge, Meiyan Yang, Yuli Wang, Li Shan, Chunsheng Gao |
Journal | Drug development and industrial pharmacy
(Drug Dev Ind Pharm)
Vol. 41
Issue 6
Pg. 934-41
(Jun 2015)
ISSN: 1520-5762 [Electronic] England |
PMID | 24785576
(Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 3-methyl-3-azabicyclo(3,3,1)nonanyl-9-alpha-yl-alpha-cyclopentyl-alpha-phenyl-alpha-glycolate
- Aza Compounds
- Cholinergic Antagonists
- Glycolates
- Ion Exchange Resins
- Tablets
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Topics |
- Administration, Oral
- Adult
- Aza Compounds
(administration & dosage, chemistry)
- Calorimetry, Differential Scanning
- Chemistry, Pharmaceutical
(methods)
- Cholinergic Antagonists
(administration & dosage, chemistry)
- Drug Compounding
(methods)
- Female
- Glycolates
(administration & dosage, chemistry)
- Humans
- Ion Exchange Resins
(chemistry)
- Male
- Microscopy, Electron, Scanning
(methods)
- Single-Blind Method
- Solubility
- Tablets
- Taste
- X-Ray Diffraction
- Young Adult
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