Abstract | AIMS: METHODS: The study comprised 239 subjects with a mean duration of occupational exposure to asbestos of 19.9 years. In all of them, a complete medical history was taken, focused on exposure duration and a physical examination, a chest X-ray or other imaging investigations and a lung function test were performed. Their serum SMRP levels were measured and biopsy samples were taken to diagnose pleural disease. Based on the above examinations, the subjects were classified into subgroups and serum SMRP concentrations were statistically analyzed with respect to individual parameters. RESULTS: In asbestos-exposed individuals, mesothelin levels were significantly higher in those with pathological X-ray findings than in those with normal X-ray results (0.78 ± 0.63 vs. 0.50 ± 0.35, P<0.0001). The group of patients with benign disease had statistically significantly higher mesothelin levels than those with normal X-ray findings (0.755 ± 0.543 vs. 0.50 ± 0.35, P<0.001). In the group with present malignant processes, mesothelin levels were higher than in individuals with benign disease (1.19 ± 0.89 vs. 0.76 ± 0.54, P=0.015). Only a weak correlation was found between mesothelin levels and asbestos exposure duration. There were relatively high sensitivity and high specificity (75% and 90.6%, respectively) of serum mesothelin for pleural mesothelioma. However, given the small number of mesothelioma cases in the group, the results cannot be considered as statistically significant. CONCLUSIONS: In persons followed up for asbestos exposure, increased mesothelin levels signalize pathological processes in the chest and correlate with severity of the disease. The study suggests that mesothelin cannot be considered a reliable marker for the early stage of malignant degeneration of pleural disease but only an additional criterion for examination of the followed-up individuals.
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Authors | Petr Jakubec, Daniela Pelclova, Petra Smolkova, Vitezslav Kolek, Marie Nakladalova |
Journal | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
(Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub)
Vol. 159
Issue 3
Pg. 472-9
(Sep 2015)
ISSN: 1804-7521 [Electronic] Czech Republic |
PMID | 24781044
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- GPI-Linked Proteins
- Asbestos
- Mesothelin
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Topics |
- Asbestos
(adverse effects)
- Asbestosis
(blood, complications, epidemiology)
- Biomarkers, Tumor
(blood)
- Czech Republic
(epidemiology)
- Female
- GPI-Linked Proteins
(blood)
- Humans
- Incidence
- Lung Neoplasms
(blood, epidemiology, etiology)
- Male
- Mesothelin
- Mesothelioma
(blood, epidemiology, etiology)
- Mesothelioma, Malignant
- Middle Aged
- Occupational Exposure
(adverse effects)
- Pleural Neoplasms
(blood, epidemiology, etiology)
- ROC Curve
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