Abstract | INTRODUCTION: MATERIALS AND METHODS: RESULTS:
Prostate cancer cells disrupt the normal bone remodeling process, invade the skeletal environment, and ultimately weaken the bone structure. This may result in skeletal complications, also known as skeletal related events (SREs), including pain, fractures, spinal cord compressions requiring surgery, radiotherapy or change in anti- cancer treatments. SREs negatively impact quality-of-life and survival and represent a major cost for the healthcare system. The bone metastases conundrum is further aggravated by the fact that androgen deprivation therapy (ADT), the reference systemic treatment of advanced prostate cancer, profoundly affects the skeletal integrity as well. ADT accelerates the physiological bone resorption, leading to osteoporosis and fragility fractures. CONCLUSION: The concept of "bone health" or "skeletal heath" refers to the diagnostic, prevention, and treatment of cancer treatment induced bone loss (CTIBL) and metastasis, and their respective complications, osteoporotic fractures and SREs.
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Authors | Valentina Butoescu, Bertrand Tombal |
Journal | The Canadian journal of urology
(Can J Urol)
Vol. 21
Issue 2 Supp 1
Pg. 84-92
(Apr 2014)
ISSN: 1195-9479 [Print] Canada |
PMID | 24775729
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Absorptiometry, Photon
- Androgen Antagonists
(adverse effects, pharmacology, therapeutic use)
- Bone Neoplasms
(epidemiology, secondary)
- Bone and Bones
(diagnostic imaging, drug effects, physiopathology)
- Disease Progression
- Humans
- Male
- Neoplasm Staging
- Practice Guidelines as Topic
- Prostatic Neoplasms
(drug therapy, pathology)
- Risk Factors
- Treatment Outcome
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