HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The effects of exercise preconditioning on cerebral blood flow change and endothelin-1 expression after cerebral ischemia in rats.

Abstract
Stroke is an acute cerebrovascular disease with high incidence, morbidity, and mortality. Preischemic treadmill training has been shown to be effective in improving behavioral and neuropathologic indices after cerebral ischemia. However, the exact neuroprotective mechanism of preischemic treadmill training against ischemic injury has not been elucidated clearly. The present study investigated whether preischemic treadmill training could protect the brain from ischemic injury via regulating cerebral blood flow (CBF) and endothelin 1 (ET-1). We analyzed the CBF by laser speckle imaging and ET-1 expression by an enzyme-linked immunosorbent assay using an ischemic rat model with preischemic treadmill training. Generally speaking, ET-1 expression decreased and CBF increased significantly in the pretreadmill group. It is worth noting that ET-1 expression is increased at 24 hours of reperfusion in the pretreadmill group compared with the level of the time after middle cerebral artery occlusion. These changes were followed by significant changes in neurologic deficits and cerebral infarct volume. This study indicated that preconditioning exercise protected brain from ischemic injury through the improvement of CBF and regulation of ET-1 expression, which may be a novel component of the neuroprotective mechanism of preischemic treadmill training against brain injury.
AuthorsQi Zhang, Li Zhang, Xiaojiao Yang, Yonggan Wan, Jie Jia
JournalJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 23 Issue 6 Pg. 1696-702 (Jul 2014) ISSN: 1532-8511 [Electronic] United States
PMID24774439 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Endothelin-1
Topics
  • Animals
  • Brain (metabolism, pathology, physiopathology)
  • Brain Ischemia (metabolism, pathology, physiopathology)
  • Cerebrovascular Circulation (physiology)
  • Disease Models, Animal
  • Endothelin-1 (metabolism)
  • Infarction, Middle Cerebral Artery (physiopathology)
  • Ischemic Preconditioning (methods)
  • Male
  • Physical Conditioning, Animal (physiology)
  • Rats
  • Rats, Sprague-Dawley
  • Stroke (metabolism, pathology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: