Possibility of usage of aminostigmine structural analogue for the treatment of toxic cognitive disorders.

Abstract

We studied the effects of 2-(hexyl(methyl)amino)methyl)pyridyl-3-dimethyl carbamate (OPDC), a structural analogue of aminostigmine oxalate, on memory formation in rats with toxic scopolamine-induced amnesia. It was shown that OPDC in non-toxic doses ((1)/215 LD50) has significant anti-amnesic action. Ipidacrine and galantamine in the doses similar to toxic doses ((1)/17 and (1)/6 of LD50, respectively) induced the retention of memory trace. Administration of aminostigmine ((1)/11 of LD50) induced unstable anti-amnesic effect in the model of scopolamine-induced amnesia.

• Authors: I V Fateev, S N Subbotina, A F Kurpyakova, M A Tyunin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 156 Issue 3 Pg. 353-6 (Jan 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 24771374 (Publication Type: Journal Article)

Chemical References

• Carbamates
• aminostigmine
• Pyridostigmine Bromide

Topics

• Animals
• Carbamates (therapeutic use)
• Cognition Disorders (drug therapy)
• Lethal Dose 50
• Male
• Pyridostigmine Bromide (analogs & derivatives, therapeutic use)
• Rats