Perspectives on clinical trials for hypertonic saline/dextran solutions for the treatment of traumatic shock.

Abstract

Animal studies with hypertonic solutions suggest that they can achieve resuscitation of hypovolemic shock with extremely small volumes. Such small volume resuscitation might be ideal in the field treatment of injured patients. Our studies to date, with 60 patients entered into a prospective, randomized, placebo-controlled, and double-blind clinical trial, suggest that the use of a 7.5% NaCl/Dextran 70 solution increases blood pressures during transport. The solutions have been safe, and we have encountered no adverse side effects from their use. Survival rates to date favor use of the solutions, but we do not have convincing statistical significance yet in that regard.

• Authors: J W Holcroft, M J Vassar, C A Perry, W L Gannaway, G C Kramer
• Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas (Braz J Med Biol Res) Vol. 22 Issue 2 Pg. 291-3 ( 1989) ISSN: 0100-879X [Print] Brazil
• PMID: 2477096 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Dextrans
• Isotonic Solutions
• Ringer's Lactate
• Saline Solution, Hypertonic

Topics

• Clinical Trials as Topic
• Dextrans (therapeutic use)
• Double-Blind Method
• Emergencies
• Fluid Therapy
• Humans
• Isotonic Solutions
• Prospective Studies
• Random Allocation
• Resuscitation (methods)
• Ringer's Lactate
• Saline Solution, Hypertonic
• Shock, Traumatic (therapy)