Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense.

Abstract

We compared anti-inflammatory activity of individual diterpene alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene alkaloids exerted no ulcerogenic effect.

• Authors: Yu V Nesterova, T N Povetieva, N I Suslov, G N Zyuz'kov, S G Aksinenko, S V Pushkarskii, A V Krapivin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 156 Issue 5 Pg. 665-8 (Mar 2014) ISSN: 1573-8221 [Electronic] United States
• PMID: 24770754 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Diterpenes
• Plant Extracts

Topics

• Aconitum (chemistry)
• Animals
• Animals, Outbred Strains
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Diterpenes (pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Edema (chemically induced, drug therapy)
• Hindlimb (drug effects, pathology)
• Mice, Inbred CBA
• Plant Extracts (pharmacology, therapeutic use)