[Case report of chemotherapeutic control of a gastric cancer producing granulocyte-colony stimulating factor].

Abstract

A 79-year-old man presented with a history of vomiting. Laboratory data indicated leukocytosis (26360/μl), and elevated granulocyte-colony stimulating factor (G-CSF) level (155 pg/ml). Upper gastrointestinal endoscopy revealed a type 3 gastric cancer, and subsequent G-CSF immunohistochemical staining of a biopsy specimen was positive. He was therefore diagnosed with a G-CSF-producing gastric cancer. Computed tomography revealed multiple liver metastases. Chemotherapy was initiated, resulting in a partial response for 5 months. G-CSF-producing gastric cancer is rare; thus, we take this opportunity to report our case and to summarize the G-CSF-producing gastric cancer cases reported in Japan.

• Authors: Masatake Miyamoto, Shunichi Misawa
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 111 Issue 4 Pg. 748-55 (Apr 2014) ISSN: 0446-6586 [Print] Japan
• PMID: 24769464 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Drug Combinations
• Granulocyte Colony-Stimulating Factor
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Irinotecan
• Cisplatin
• Camptothecin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (administration & dosage, analogs & derivatives)
• Cisplatin (administration & dosage)
• Drug Combinations
• Fatal Outcome
• Gastroscopy
• Granulocyte Colony-Stimulating Factor (biosynthesis)
• Humans
• Irinotecan
• Liver Neoplasms (diagnostic imaging, drug therapy, secondary)
• Male
• Oxonic Acid (administration & dosage)
• Stomach Neoplasms (diagnosis, drug therapy, metabolism, pathology)
• Tegafur (administration & dosage)
• Tomography, X-Ray Computed