Inhibitory actions of procaterol, a beta-2 stimulant, on substance P-induced cough in normal subjects during upper respiratory tract infection.

Abstract

We studied substance P (SP)-induced cough in normal subjects without and with colds, and the effects of orally administered procaterol on SP-induced cough in normal subjects with colds. SP aerosols caused cough at a concentration of approximately 10(-15) M in subjects with colds whereas it did not cause cough at a concentration of up to 10(-5) M in subjects without colds. Procaterol (50 micrograms) completely inhibited SP-induced cough in normal subjects with colds. These results suggest that cough response to SP remarkably increases during colds and that beta-2 stimulant may be a useful tool for treatment of cough during colds in normal subjects.

• Authors: U Katsumata, K Sekizawa, H Inoue, H Sasaki, T Takishima
• Journal: The Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 158 Issue 1 Pg. 105-6 (May 1989) ISSN: 0040-8727 [Print] Japan
• PMID: 2476867 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Ethanolamines
• Substance P
• Procaterol

Topics

• Adrenergic beta-Agonists (pharmacology)
• Adult
• Cough (chemically induced, physiopathology)
• Ethanolamines (pharmacology)
• Female
• Forced Expiratory Volume
• Humans
• Male
• Procaterol
• Respiratory Tract Infections (physiopathology)
• Substance P