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[Efficacy of triple versus quadruple furazolidone-based eradication regimens for Helicobacter pylori infection].

AbstractOBJECTIVE:
To explore the eradication efficacies of triple versus quadruple furazolidone-based regimens for Helicobacter pylori (H. pylori) infection.
METHODS:
A total of 357 outpatients with H. pylori infection were enrolled from June to December 2010. There were 200 males and 157 females with an average age of (42 ± 12) years. A diagnosis of duodenal ulcer was made according to their endoscopic examination results. They were randomly assigned into 4 treatment groups: 7-day triple (n = 89) and 10-day triple (n = 91), rabeprazole 10 mg, amoxicillin 1 000 mg and furazolidone 100 mg twice daily for 7 and 10 days respectively. 7-day quadruple (n = 88) and 10-day quadruple (n = 89), rabeprazole 10 mg, bismuth 220 mg, amoxicillin 1 000 mg and furazolidone 100 mg twice daily for 7 and 10 days respectively.H. pylori status was re-assessed with (14)C-urea breath test after 4-week therapy.
RESULTS:
Among them, 323 cases completed the study. According to the analysis of intention-to-treat (ITT), the H. pylori eradication rates were 71.91% (64/89) in 7-day triple, 81.32% (74/91) in 10-day triple, 78.41% (69/88) in 7-day quadruple and 83.15% (74/89) in 10-day quadruple groups. No significant deviation existed among all groups (P > 0.05). According the per-protocol (PP) analysis, H. pylori eradication rates were 78.05% (64/82) in 7-day triple, 88.10% (74/84) in 10-day triple, 87.34% (69/79) in 7-day quadruple and 94.87% (74/78) in 10-day quadruple groups. Significant deviation existed among all groups (P = 0.017). The H. pylori eradication rate in 10-day quadruple group was significantly higher than that in 7-day triple group (P = 0.002). The total adverse reaction rate was 7.00% (25/357). No significant difference existed among all groups (P > 0.05).
CONCLUSIONS:
Quadruple treatments provide higher H. pylori eradication rates than triple therapies. A 10-day treatment may improve H. pylori eradication rate. And 10-day quadruple regimen with furazolidone and bismuth may be effective for H. pylori infection.
AuthorsZhifa Lü, Yong Xie, Nonghua Lü, Hong Zhou, Zhijian Liu, Xuan Zhu, Youxiang Chen, Xingxing He, Dongsheng Liu, Jiuhong Ma
JournalZhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 94 Issue 8 Pg. 572-5 (Mar 04 2014) ISSN: 0376-2491 [Print] China
PMID24762683 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Furazolidone
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Furazolidone (administration & dosage, therapeutic use)
  • Helicobacter Infections (drug therapy)
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Young Adult

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