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Evaluation of hepatocyteprotective and anti-hepatitis B virus properties of Cichoric acid from Cichorium intybus leaves in cell culture.

Abstract
Hepatitis B is the most common serious liver infection in the world. To date, there is still no complete cure for chronic hepatitis B. Natural caffeic acid analogues possess prominent antiviral activity, especially anti-hepatitis B virus (HBV) and anti-human immunodeficiency virus effects. Cichoric acid is a caffeic acid derivative from Cichorium intybus. In the study, the anti-hepatitis B property of cichoric acid was evaluated by the D-galactosamine (D-GalN)-induced normal human HL-7702 hepatocyte injury model, the duck hepatitis B virus (DHBV)-infected duck fetal hepatocytes and the HBV-transfected cell line HepG2.2.15 cells, respectively. The results showed that cichoric acid attenuated significantly D-GalN-induced HL-7702 hepatocyte injury at 10-100 µg/mL and produced a maximum protection rate of 56.26%. Moreover, cichoric acid at 1-100 µg/mL inhibited markedly DHBV DNA replication in infected duck fetal hepatocytes. Also, cichoric acid at 10-100 µg/mL reduced significantly the hepatitis B surface and envelope antigen levels in HepG2.2.15 cells and produced the maximum inhibition rates of 79.94% and 76.41%, respectively. Meanwhile, test compound at 50-100 µg/mL inhibited markedly HBV DNA replication. In conclusion, this study verifies the anti-hepatitis B effect of cichoric acid from Cichorium intybus leaves. In addition, cichoric acid could be used to design the antiviral agents.
AuthorsHong-Li Zhang, Ling-Hao Dai, Yi-Hang Wu, Xiao-Ping Yu, Yong-Yong Zhang, Rong-Fa Guan, Tao Liu, Jun Zhao
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 37 Issue 7 Pg. 1214-20 ( 2014) ISSN: 1347-5215 [Electronic] Japan
PMID24759764 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Caffeic Acids
  • DNA, Viral
  • Hepatitis B Surface Antigens
  • Protective Agents
  • Succinates
  • Galactosamine
  • chicoric acid
Topics
  • Animals
  • Caffeic Acids (isolation & purification, pharmacokinetics)
  • Cell Survival (drug effects)
  • Chicory (chemistry)
  • Cytoprotection (drug effects)
  • DNA, Viral (drug effects)
  • Dose-Response Relationship, Drug
  • Ducks
  • Galactosamine (pharmacology)
  • Hep G2 Cells
  • Hepatitis B Surface Antigens (metabolism)
  • Hepatitis B Virus, Duck (drug effects, genetics, growth & development)
  • Hepatocytes (drug effects, virology)
  • Humans
  • Molecular Structure
  • Plant Leaves (chemistry)
  • Protective Agents (isolation & purification, pharmacology)
  • Succinates (isolation & purification, pharmacokinetics)
  • Virus Replication (drug effects)

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