Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing.
Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSION: Our findings indicate that PDE2A contributes to the processing of inflammatory pain in the spinal cord.
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Authors | Wiebke Kallenborn-Gerhardt, Ruirui Lu, Aaron Bothe, Dominique Thomas, Jessica Schlaudraff, Jana E Lorenz, Nancy Lippold, Catherine I Real, Nerea Ferreirós, Gerd Geisslinger, Domenico Del Turco, Achim Schmidtko |
Journal | Anesthesiology
(Anesthesiology)
Vol. 121
Issue 2
Pg. 372-82
(Aug 2014)
ISSN: 1528-1175 [Electronic] United States |
PMID | 24758774
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one
- Imidazoles
- Phosphodiesterase Inhibitors
- Triazines
- Zymosan
- Cyclic AMP
- Cyclic Nucleotide Phosphodiesterases, Type 2
- Cyclic GMP
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Topics |
- Animals
- Behavior, Animal
(drug effects, physiology)
- Cyclic AMP
(metabolism)
- Cyclic GMP
(metabolism)
- Cyclic Nucleotide Phosphodiesterases, Type 2
(biosynthesis, metabolism, physiology)
- Drug Hypersensitivity
(physiopathology)
- Imidazoles
(administration & dosage, pharmacology)
- Immunohistochemistry
- Inflammation
(complications, enzymology, physiopathology)
- Injections, Spinal
- Male
- Mice
- Mice, Inbred C57BL
- Microdissection
- Neuralgia
(enzymology, physiopathology, psychology)
- Pain
(enzymology, etiology, physiopathology)
- Pain Measurement
- Phosphodiesterase Inhibitors
(administration & dosage, pharmacology)
- Posterior Horn Cells
(enzymology)
- Real-Time Polymerase Chain Reaction
- Spinal Cord
(enzymology)
- Triazines
(administration & dosage, pharmacology)
- Up-Regulation
(genetics, physiology)
- Zymosan
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