Abstract | OBJECTIVE: The purpose of this study was to establish the correlation and reliability among the pathologic tumor volume and gradient and fixed threshold segmentations of (18)F-FDG PET metabolic tumor volume of human solid tumors. MATERIALS AND METHODS: There were 52 patients included in the study who had undergone baseline PET/CT with subsequent resection of head and neck, lung, and colorectal tumors. The pathologic volume was calculated from three dimensions of the gross tumor specimen as a reference standard. The primary tumor metabolic tumor volume was segmented using gradient and 30%, 40%, and 50% maximum standardized uptake value (SUVmax) threshold methods. Pearson correlation coefficient, intraclass correlation coefficient, and Bland-Altman analyses were performed to establish the correlation and reliability among the pathologic volume and segmented metabolic tumor volume. RESULTS: The mean pathologic volume; gradient-based metabolic tumor volume; and 30%, 40%, and 50% SUVmax threshold metabolic tumor volumes were 13.46, 13.75, 15.47, 10.63, and 7.57 mL, respectively. The intraclass correlation coefficients among the pathologic volume and the gradient-based and 30%, 40%, and 50% SUVmax threshold metabolic tumor volumes were 0.95, 0.85, 0.80, and 0.76, respectively. The Bland-Altman biases were -0.3, -2.0, 2.82, and 5.9 mL, respectively. Of the small tumors (< 10 mL), 23 of the 35 patients had PET segmented volume outside 50% of the pathologic volume, and among the large tumors (≥ 10 mL) three of the 17 patients had PET segmented volumes that were outside 50% of pathologic volume. CONCLUSION: FDG PET metabolic tumor volume estimated using gradient segmentation had superior correlation and reliability with the estimated ellipsoid pathologic volume of the tumors compared with threshold method segmentation.
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Authors | Praveen Sridhar, Gustavo Mercier, Josenia Tan, Minh Tam Truong, Benedict Daly, Rathan M Subramaniam |
Journal | AJR. American journal of roentgenology
(AJR Am J Roentgenol)
Vol. 202
Issue 5
Pg. 1114-9
(May 2014)
ISSN: 1546-3141 [Electronic] United States |
PMID | 24758668
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Aged
- Aged, 80 and over
- Female
- Fluorodeoxyglucose F18
- Humans
- Male
- Middle Aged
- Multimodal Imaging
- Neoplasms
(metabolism, pathology)
- Positron-Emission Tomography
- Radiopharmaceuticals
- Reproducibility of Results
- Retrospective Studies
- Tumor Burden
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